During sleep and anesthesia, a slow (<or=1 Hz) synchronized rhythmic fluctuation of the network activity in the neocortex (nCTX) is prominent. This rhythm, called the slow oscillation (SO), corresponds to sequences of neuronal activity and inactivity (UP and DOWN states) in local and extended networks. Recently, this network pattern has also been described in the hippocampus (HPC) and, interest...

Anesthetics are often used to characterize the activity of single neurons in vivo for their advantages such as reduction of noise level and convenience in noxious stimulations. Urethane has been a widely used anesthetic in thalamic studies under the assumption that sensory signals are still relayed to the thalamus under urethane anesthesia and that thalamic response would therefore reflect the ...

AIM To test if anesthetic procedures change the hemodynamic pattern in animals with experimental septic shock. METHODS The effect of two anesthetics on systemic hemodynamic and skeletal muscle microcirculatory responses in high cardiac output live E. coli bacteremia was studied in rats and compared to the effect of two other anesthetic procedures in previously published studies. RESULTS Bas...

INTRODUCTION Spontaneous low frequency fMRI fluctuations measured during resting-state have been shown to provide important information on spontaneous neuronal activity and the functional organization of the brain [1]. Although many resting-state fMRI studies have been performed on human subjects, only a handful of studies have been conducted in rat models. The major concern in rodents and in a...

OBJECTIVE To investigate the changes of auditory parameters during anesthesia and establish the assessment indicators for anesthesia monitoring in animal experiments. METHODS BALB/c mice of 4 to 6 weeks were given a single intraperitoneal dose of urethane, and the auditory evoked potential in the surgically exposed inferior colliculus in response to pure tone stimulation was recorded during u...

I.v. propranolol (Prop) produced sustained pressor responses in rats but not in dogs under urethane anesthesia. In the dogs there was a progressive reduction in systolic blood pressure (SBP) in accordance with a significant heart rate (HR) reduction. Even at the i.v. dose (5 mg/kg) where vasoconstrictor response to i.v. norepinephrine (NE) is changed to the vasodilator one in rats, phenoxybenza...

Procedures involving complex surgical techniques in rats, such as placement of abdominal aortic graft require extended duration of surgical anesthesia, which often can be achieved by repeated administrations of xylazine-ketamine combination. However such repeated anesthetic administration, in addition to being technically challenging, may be associated with potential adverse events due to cumul...

The expression of Fos, the protein product of the primary response gene c-fos, was used metabolically to map the short-term (1 hr) effects of urethane and sodium pentobarbital anesthesia in rat. Subsequently, urethane-anesthetized rats were used to study the integrated response to electrical stimulation (1-1.5 hr) of the pontine parabrachial nucleus (PBN), an important center for relay of auton...

s in refered journals 1. Szentgyörgyi V., Détári L. and Kukorelli T. Dependency of evoked potentials on the burst-suppression pattern of the EEG in deep urethane anesthesia in rats Neurobiol., 5 (1997) 216-217 2. Détári L., Szentgyörgyi V. and Kukorelli T. High frequency cortical activity in deep urethane anesthesia in rats. Neurobiol., 5 (1997) 119-120 3. Szentgyörgyi, V., Détári, L., Hajnik, ...

Urethane is widely used in neurophysiological experiments to anesthetize animals, yet little is known about its actions at the cellular and synaptic levels. This limits our ability to model systems-level cortical function using results from urethane-anesthetized preparations. The present study found that action potential discharge of cortical neurons in vitro, in response to depolarizing curren...